Betty Boop is an animated cartoon character created by Max Fleischer. Despite having been toned down in the mid-1930s to appear more demure, she became one of the best-known and popular cartoon characters in the world.
1945's The Friendly Ghost by Paramount is a disturbing cartoon even by today's standards. In his first adventure Casper, The Friendly Ghost wanted to run away from home and commit suicide. Having forgotten he was already dead. =/ Though that hasn't deterred the tiny transparent ray of sunshine from maintaining posthumous longevity. Recently as the 1990's he returned with his own movie franchise and tie-in animated series.